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The 2009 film was not a massive box office hit, which likely made studios hesitant to finance a direct follow-up. The production of a follow-up, tentatively titled Splice 2: Dren in the City , was reportedly planned for a 2011 release but was ultimately shelved. Director Vincenzo Natali has also been open about his reluctance to create a sequel simply for commercial reasons. His experience with the Cube sequels, which he felt were a mistake, made him cautious about revisiting Splice without a compelling new story to tell. For users looking to "splice" (merge) and translate

Geneticists Clive and Elsa successfully create a new animal-human hybrid named Dren . What begins as a scientific breakthrough quickly devolves into a psychological and physical nightmare as Dren grows at an accelerated rate and develops dangerous, unpredictable traits. The production of a follow-up, tentatively titled Splice

To avoid confusion, it's worth noting there is also a very popular video editing application called , now owned by Bending Spoons (formerly GoPro).

Sites like YouTube and Dailymotion host "Splice 2" clips, though many are high-definition (HD) trailers for the original 2009 film or fan-edited concepts using footage from other sci-fi horror movies.